Narender R Gavva Selected Research

N- (4- (6- (4- (1- (4- fluorophenyl)ethyl)piperazin- 1- yl)pyrimidin- 4- yloxy)benzo(d)thiazol- 2- yl)acetamide

7/2007

Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.

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Narender R Gavva Research Topics

Disease

20	Pain (Aches) 03/2016 - 04/2005
9	Hyperalgesia 04/2015 - 04/2005
6	Hyperthermia 01/2010 - 03/2007
4	Hypothermia 03/2014 - 11/2008
3	Migraine Disorders (Migraine) 12/2019 - 04/2015
3	Neurogenic Inflammation 01/2016 - 12/2007
3	Chronic Pain 05/2012 - 10/2006
2	Hypersensitivity (Allergy) 01/2016 - 04/2015
2	Asthma (Bronchial Asthma) 01/2016 - 08/2014
2	Cough 01/2016 - 08/2014
2	Neuralgia (Stump Neuralgia) 01/2016 - 04/2009
2	Neoplasms (Cancer) 04/2009 - 05/2008
2	Inflammation (Inflammations) 04/2009 - 12/2002
1	Sepsis (Septicemia) 01/2012
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2012
1	Necrosis 05/2011
1	Morton Neuroma 04/2009
1	Diabetic Neuropathies (Diabetic Neuropathy) 04/2009
1	Postherpetic Neuralgia 04/2009
1	Interstitial Cystitis (Interstitial Cystitis, Chronic) 04/2009
1	Postoperative Pain 04/2009
1	Osteoarthritis 04/2009
1	Acute Pain 05/2008
1	Cancer Pain 03/2007
1	Sensation Disorders 05/2004
1	Ischemia 12/2002
1	Infarction (Infarctions) 12/2002

Drug/Important Bio-Agent (IBA)

12	Capsaicin (Zostrix)FDA Link 01/2010 - 05/2004
5	TRPV Cation ChannelsIBA 07/2008 - 10/2006
5	Freund's AdjuvantIBA 07/2008 - 04/2005
4	2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate (AITC)IBA 03/2016 - 12/2007
3	CationsIBA 01/2018 - 03/2007
3	Analgesics (Analgesic Drugs)IBA 06/2008 - 03/2007
3	N- (4- (6- (4- trifluoromethylphenyl)pyrimidin- 4- yloxy)benzothiazol- 2- yl)acetamideIBA 05/2008 - 10/2007
2	TRPA1 Cation ChannelIBA 01/2016 - 08/2014
2	allyl isothiocyanateIBA 01/2016 - 08/2014
2	AnkyrinsIBA 01/2016 - 08/2014
2	AMG2850IBA 04/2015 - 03/2014
2	resiniferatoxinIBA 05/2011 - 04/2009
2	Protons (Proton)IBA 01/2010 - 03/2007
2	N- (7- hydroxy- 5,6,7,8- tetrahydronaphthalen- 1- yl)- 3- (2- (piperidin- 1- yl)- 6- (trifluoromethyl)pyridin- 3- yl)acrylamideIBA 06/2008 - 07/2007
1	NucleotidesIBA 12/2019
1	AMG 333IBA 01/2018
1	AcidsIBA 01/2018
1	Therapeutic UsesIBA 04/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012
1	RimonabantIBA 05/2011
1	capsazepineIBA 05/2011
1	SR 144528IBA 05/2011
1	3- (4- chlorophenyl)- N- methyl- N'- ((4- chlorophenyl)sulfonyl)- 4- phenyl- 4,5- dihydro- 1H- pyrazole- 1- carboxamidineIBA 05/2011
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 05/2011
1	CB2 Cannabinoid ReceptorIBA 05/2011
1	ALGRX-4975IBA 04/2009
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2008
1	(R,E)- N- (2- hydroxy- 2,3- dihydro- 1H- inden- 4- yl)- 3- (2- (piperidin- 1- yl)- 4- (trifluoromethyl)phenyl)- acrylamideIBA 07/2008
1	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 06/2008
1	Morphine (MS Contin)FDA LinkGeneric 06/2008
1	Formaldehyde (Formol)FDA Link 12/2007
1	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2007
1	AntipyreticsIBA 10/2007
1	N- (4- (6- (4- (1- (4- fluorophenyl)ethyl)piperazin- 1- yl)pyrimidin- 4- yloxy)benzo(d)thiazol- 2- yl)acetamideIBA 07/2007
1	Ion Channels (Ion Channel)IBA 07/2007
1	3- (4- t- butylphenyl)- N- (2,3- dihydrobenzo(b)(1,4)dioxin- 6- yl)acrylamideIBA 04/2005
1	Interferon-gamma (Interferon, gamma)IBA 12/2002
1	Digoxin (Digitek)FDA LinkGeneric 12/2002
1	Carrier Proteins (Binding Protein)IBA 12/2002
1	CalciumIBA 12/2002
1	Proteins (Proteins, Gene)FDA Link 12/2002
1	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 12/2002
1	Messenger RNA (mRNA)IBA 12/2002
1	CytokinesIBA 12/2002
1	Synapsins (Synapsin I)IBA 12/2002
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2002
1	GalaninIBA 12/2002
1	silencer factor BIBA 12/2002
1	vesicular GABA transporterIBA 12/2002
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2002
1	neurotriminIBA 12/2002
1	Cyclic AMP Response Element ModulatorIBA 12/2002

Therapy/Procedure

9	Therapeutics 12/2019 - 10/2006
2	Ligation 01/2012 - 12/2007
1	Oral Administration 01/2016
1	Punctures 01/2012
1	Analgesia 04/2009
1	Induced Hyperthermia (Thermotherapy) 07/2008
1	Induced Hypothermia 07/2007